Our Research

Research Summary Update

Summary of Completed Research in Prolotherapy and Bioregenerative Injection K. Dean Reeves, M.D., Clinical Associate Professor, University of Kansas “This work is provided under the Creative Commons Attribution 3.0 Unported License.”

How Injections Work

Explanation of Prolotherapy and Perineural Injection Therapy (Perineural Subcutaneous Injection and Perineural Deep Injection) Definition: Prolotherapy is injection whose primary intent is to repair connective tissue (that is, ligament, tendon or cartilage).

Prolotherapy is Not Experimental

Most state boards of medicine have definitions for what is experimental and what is not. Those definitions are based on two major issues. In general, if a procedure as taught by post graduate programs for the healing arts and has level II (out of IV) data in multiple areas, it is not considered experimental. Click to read more about why prolotherapy is not experimental.

Individual Prolotherapy Study Summaries


Achilles Tendinosis

ACL Laxity

Baker’s Cyst

Coccygeal Pain

Degenerative Disc

Finger Arthritis

Groin Pain

Knee Arthritis

Low Back Pain

Medial Meniscus Tear

Neck Pain


Patellar Tendinosis

Plantar Fasciosis

Sacroiliac Pain

Shin Splints

Tennis Elbow

TMJ Pain Dysfunction